Endocrine Abstracts

Introduction: Cyclic Cushing’s Syndrome (CCS) is a rare disorder in which rhythmic fluctuations in the secretion of ACTH trigger cyclic variations in the production of adrenal steroids and an extremely variable clinical presentation. It should be considered when clinical hypercortisolism coexists with normal cortisol levels and a paradoxical response to the dexamethasone test, and when selective transsphenoidal adenomectomy fails after an uncomplicated intervention.<p...

Introduction: McCune Albright syndrome (MAS) is a rare, sporadic disease that affects the skin, skeleton and several endocrine systems, caused by an activating mutation in the GNAS gene that leads to endocrine cell hyperfunction and increased cell proliferation. The development of thyroid carcinoma in MAS is considered an uncommon event and, on the other hand, it is well established that acromegaly is associated with an increased prevalence of malignant tumors including thyroi...

Introduction: Neuroendocrine tumors (NETs) are rare and their clinical behavior and prognosis correlates with mitotic rate and Ki-67 index. Most patients with advanced NET have liver metastases unresectable and somatostatin analogues are the initial therapy of choice but when disease progresses despite treatment and there are positive somatostatin receptors, peptide receptor radioligand therapy (PRRT), using lutetium-177, is a therapeutic option.Clinical...

Introduction: Acromegaly increases morbidity and mortality and should be treated even in the asymptomatic phase. It is almost always caused by a GH-producing pituitary adenoma and although transsphenoidal surgery is the treatment of choice in most cases, in others, primary medical therapy is indicated.Clinical case: A 36-year-old female with a family history of thyroid functional pathology and diagnosed with micronodular goiter was evaluated in February ...

Introduction: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) therapyhas proven effective in type 2 diabetes but there is little data on its effect in patients with psychiatric comorbidity, who usually present worse metabolic and clinical control. The aim of this study was to evaluate if there are differences in the effect of this therapy in relation to the presence of these pathologies.Methods: 225 patients included in a therapy protocol with SGLT2i,...